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Mesothelioma Victims Might Find Hope from Clinical Trials of New Treatments

July 21st, 2009

Cancer doctors determine what course of treatment to administer for each patient. There are numerous options. There exists no regular treatment regimen for pleural mesothelioma patients. Mesotheliomas lack of agreed-upon treatment is due to low a treatment success rate, rareness, a high mortality rate and a small number of studies providing meaningful stats.

Mesothelioma patients have historically had a bleak outlook, but doctors have recently made progress. Customary treatments for cancer are surgery (removing the tumor and the tissue that surrounds it), chemotherapy (poisoning cancerous cells) and radiation (killing cancer cells with radiation) All three methods have problems. Patients with mesothelioma have not responded well to traditional radiation therapy. In hopes to lessen damage to healthy tissue, researches are studying ways to aim radiation right at the tumor.

Surgery takes out the mesothelial cancerous tissue around the tumor. This surgery is extensive and it is not clear how much the patient benefits. The usual chemotherapy cocktails effective on other cancers are not effective on mesothelioma, and different mixtures of these drugs have not been successful. Like radiation, researchers are focusing their work on controlling the physical location of the treatment with an emphasis on the pleural cavity.

Many advanced techniques in cancer treatment are tried on mesothelioma patients because of its high fatality rate. These include biologic therapy such as the agent interleukin 2 and anti-angiogenesis drugs such as thalidomide. Pemetrexed (Alimta) is a new drug that has shown results in extending life.

Oncologists consider the stage of mesothelioma, the location of the tumor, the patient’s age and state of health at the time. Two exotic ways of attacking mesothelioma are gene therapy and photodynamic therapy. Mesothelioma patients sometimes become involved in clinical trials in this area, and see benefits.

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